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Discussion: Bravo!

in: BP; BP > 2020-03-31

Apr 1, 2020 10:27 PM # 
matzah ball:
Bravo!
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Apr 2, 2020 2:18 PM # 
JanetT:
In your professional opinion, does this cure sound too good to be true to you? (Delanson is west of Albany NY).

Or are there lots of existing potential treatments that just need to be tested?
Apr 2, 2020 8:58 PM # 
BP:
Interesting question.
Yes a lot of interesting candidate treatments out there which need to be tested in the specific circumstances of mitigating the respiratory consequences of COVID-19. Especially in the case of Antibody/vaccine therapies there is the potential for the SARS-CoV-2 to use these agent so enhance the attack on lung cells.
What is emerging is that the severity of the reactions / outcomes are related to a) dose of viral particles and b) host defense mechanisms; meaning that severe disease is related to either a very high viral inoculum (eg healthcare workers dying) and / or to impaired immune status (eg old age susceptibility). Timing of intervention is also key, which is why there appears to be limited success with potent agents like tociluzimab. So beyond nailing the virus at the front end, this is going to be vey individual-specific treatment.
TML is an old immunomodulant that might have some relevant activity, but again would need to be tested in a robust manner to move it from anecdotal evidence to broadly useful intervention.
Probably more than you asked for here!
Apr 2, 2020 9:28 PM # 
JanetT:
No, not more; I want to understand as much as I can.
Apr 2, 2020 10:07 PM # 
kensr:
Your insights are very helpful.

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