I have that problem when I wear it on my left arm. It just seems odd to reach over the start/stop and do the lap. Heidi puts a piece of tape over her start/stop to remind her not to hit that one.
But I have to remember to start/stop it! :-) I think I'd do fine if the print were large enough to see (I don't usually wear reading glasses when I run!), but I have to squint. Once I get used to it, though, I think I'll be fine.
The Garmin people obviously didn't look at other chronograph watches out there when they designed theirs. :-)